28114

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3770944..3771473 Replicon chromosome
Accession NC_018143
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag RVBD_RS17750 Protein ID WP_003417760.1
Coordinates 3771216..3771473 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag RVBD_RS17745 Protein ID WP_003417757.1
Coordinates 3770944..3771219 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVBD_RS22810 3767742..3769179 - 1438 Protein_3478 FAD-binding oxidoreductase -
RVBD_RS17730 3769282..3769671 + 390 WP_003417745.1 DUF732 domain-containing protein -
RVBD_RS17735 3769685..3769978 - 294 WP_003417749.1 DUF3017 domain-containing protein -
RVBD_RS17740 3769975..3770820 - 846 WP_003417751.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
RVBD_RS17745 3770944..3771219 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
RVBD_RS17750 3771216..3771473 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
RVBD_RS17755 3771515..3772705 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
RVBD_RS17760 3772822..3773190 + 369 WP_003417765.1 FHA domain-containing protein -
RVBD_RS17765 3773187..3773738 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
RVBD_RS17770 3773745..3774326 - 582 WP_003417769.1 ATP/GTP-binding protein -
RVBD_RS17775 3774307..3774675 - 369 WP_003417772.1 DUF742 domain-containing protein -
RVBD_RS17780 3774653..3775045 - 393 WP_003417776.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T28114 WP_003417760.1 NC_018143:3771216-3771473 [Mycobacterium tuberculosis H37Rv]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T28114 NC_018143:3771216-3771473 [Mycobacterium tuberculosis H37Rv]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTGGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT28114 WP_003417757.1 NC_018143:3770944-3771219 [Mycobacterium tuberculosis H37Rv]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT28114 NC_018143:3770944-3771219 [Mycobacterium tuberculosis H37Rv]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References