Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB-HicA
Location 326813..327380 Replicon chromosome
Accession NZ_CP124733
Organism Agrobacterium larrymoorei strain CFBP5477

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag CFBP5477_RS01505 Protein ID WP_084631408.1
Coordinates 327219..327380 (-) Length 54 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CFBP5477_RS01500 Protein ID WP_137393234.1
Coordinates 326813..327214 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CFBP5477_RS01485 (CFBP5477_001485) 322414..325065 + 2652 WP_137393231.1 DNA translocase FtsK -
CFBP5477_RS01490 (CFBP5477_001490) 325182..325907 + 726 WP_234882828.1 outer membrane lipoprotein carrier protein LolA -
CFBP5477_RS01495 (CFBP5477_001495) 325996..326799 + 804 WP_137393233.1 exodeoxyribonuclease III -
CFBP5477_RS01500 (CFBP5477_001500) 326813..327214 - 402 WP_137393234.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CFBP5477_RS01505 (CFBP5477_001505) 327219..327380 - 162 WP_084631408.1 type II toxin-antitoxin system HicA family toxin Toxin
CFBP5477_RS01510 (CFBP5477_001510) 327460..327915 - 456 WP_137393235.1 cyclic nucleotide-binding domain-containing protein -
CFBP5477_RS01515 (CFBP5477_001515) 328058..328741 - 684 WP_027673544.1 response regulator transcription factor -
CFBP5477_RS01520 (CFBP5477_001520) 328885..329430 + 546 WP_137393236.1 L,D-transpeptidase -
CFBP5477_RS01525 (CFBP5477_001525) 329563..330135 - 573 WP_027673546.1 CarD family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(11-50)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 54 a.a.        Molecular weight: 5841.95 Da        Isoelectric Point: 11.8222

>T281132 WP_084631408.1 NZ_CP124733:c327380-327219 [Agrobacterium larrymoorei]
MKSTDIIAALRKGSHVQFKHASKPGRVTVPHPKRDLPIGTLKSIEKQAGLKLR

Download         Length: 162 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14304.08 Da        Isoelectric Point: 4.5459

>AT281132 WP_137393234.1 NZ_CP124733:c327214-326813 [Agrobacterium larrymoorei]
MRNYIGLIHKHADSDYGVSFPDFPGVVTAGTDLDDARLMAEEALSLHVEGLLEDGDAIPEPSSLDDVMKDGENKMAVAIL
VSLKSESKRAVRLNITLPEDVLRDIDAYAQAHGLTRSGFLARAAKHEISSASA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References