Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3707813..3708487 Replicon chromosome
Accession NC_018143
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name vapC Uniprot ID P9WF52
Locus tag RVBD_RS17555 Protein ID WP_003417282.1
Coordinates 3707813..3708241 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TI59
Locus tag RVBD_RS17560 Protein ID WP_003417286.1
Coordinates 3708245..3708487 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVBD_RS17530 3703635..3704036 - 402 WP_003417264.1 cytidine deaminase -
RVBD_RS17535 3704177..3704611 + 435 WP_003900017.1 succinate dehydrogenase, cytochrome b556 subunit -
RVBD_RS17540 3704608..3705042 + 435 WP_009936281.1 succinate dehydrogenase hydrophobic membrane anchor subunit -
RVBD_RS17545 3705171..3706943 + 1773 WP_003417273.1 succinate dehydrogenase flavoprotein subunit -
RVBD_RS17550 3706943..3707734 + 792 WP_003417279.1 succinate dehydrogenase iron-sulfur subunit -
RVBD_RS17555 3707813..3708241 - 429 WP_003417282.1 type II toxin-antitoxin system VapC family toxin Toxin
RVBD_RS17560 3708245..3708487 - 243 WP_003417286.1 ribbon-helix-helix domain-containing protein Antitoxin
RVBD_RS17565 3708609..3709223 - 615 WP_003417288.1 class I SAM-dependent methyltransferase -
RVBD_RS17570 3709220..3709885 - 666 WP_003417290.1 molybdopterin converting factor subunit 1 -
RVBD_RS17575 3709886..3710419 - 534 WP_003417293.1 cyclic pyranopterin monophosphate synthase MoaC -
RVBD_RS22545 3710416..3710568 - 153 WP_003916129.1 hypothetical protein -
RVBD_RS17590 3710604..3711865 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15834.16 Da        Isoelectric Point: 8.5471

>T28113 WP_003417282.1 NC_018143:c3708241-3707813 [Mycobacterium tuberculosis H37Rv]
MRALLDVNVLLALLDRDHVDHERARAWITGQIERGWASCAITQNGFVRVISQPRYPSPISVAHAIDLLARATHTRYHEFW
SCTVSILDSKVIDRSRLHSPKQVTDAYLLALAVAHDGRFVTFDQSIALTAVPGATKQHLATL

Download         Length: 429 bp

>T28113 NC_018143:c3708241-3707813 [Mycobacterium tuberculosis H37Rv]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8849.86 Da        Isoelectric Point: 5.1007

>AT28113 WP_003417286.1 NC_018143:c3708487-3708245 [Mycobacterium tuberculosis H37Rv]
MRTTLSIDDDVLLAVKERARREKRTAGEILSDLARQALTNQNPQPAASQEDAFHGFEPLPHRGGAVSNALIDRLRDEEAV

Download         Length: 243 bp

>AT28113 NC_018143:c3708487-3708245 [Mycobacterium tuberculosis H37Rv]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4FBL0

Antitoxin

Source ID Structure
AlphaFold DB G0TI59

References