Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2283109..2283731 Replicon chromosome
Accession NZ_CP124732
Organism Pseudomonas sp. GM17

Toxin (Protein)


Gene name hicA Uniprot ID A0A2N8AR08
Locus tag PMI20_RS10320 Protein ID WP_007929414.1
Coordinates 2283549..2283731 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PMI20_RS10315 Protein ID WP_007929416.1
Coordinates 2283109..2283516 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMI20_RS10295 (PMI20_010295) 2278413..2279303 + 891 WP_007929421.1 LysR family transcriptional regulator -
PMI20_RS10300 (PMI20_010300) 2279541..2281319 + 1779 WP_007929420.1 GGDEF domain-containing phosphodiesterase -
PMI20_RS10305 (PMI20_010305) 2281353..2282267 - 915 WP_007929418.1 SGNH/GDSL hydrolase family protein -
PMI20_RS10310 (PMI20_010310) 2282397..2282864 - 468 WP_007929417.1 GAF domain-containing protein -
PMI20_RS10315 (PMI20_010315) 2283109..2283516 - 408 WP_007929416.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PMI20_RS10320 (PMI20_010320) 2283549..2283731 - 183 WP_007929414.1 type II toxin-antitoxin system HicA family toxin Toxin
PMI20_RS10330 (PMI20_010330) 2284440..2285324 - 885 WP_007929412.1 alpha/beta hydrolase -
PMI20_RS10335 (PMI20_010335) 2285676..2286368 - 693 WP_007929410.1 16S rRNA pseudouridine(516) synthase -
PMI20_RS10340 (PMI20_010340) 2286402..2286620 - 219 WP_274517825.1 cysteine-rich CWC family protein -
PMI20_RS10345 (PMI20_010345) 2286628..2288115 - 1488 WP_007929401.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6850.15 Da        Isoelectric Point: 11.6709

>T281126 WP_007929414.1 NZ_CP124732:c2283731-2283549 [Pseudomonas sp. GM17]
VNSRYLIGQIVADGWYLVRVRGSHHHFRHPSKPGLVTVPHPKKDLLRKTAISILKQALLM

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14670.66 Da        Isoelectric Point: 4.4699

>AT281126 WP_007929416.1 NZ_CP124732:c2283516-2283109 [Pseudomonas sp. GM17]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGDDLDDAMAMAREAIEGHFEILAEDGAPIPHANKVTLHAANPQYAGCTWAL
IDIDVTKYLGKAQKLNITLPGYLLNRIDEYVLHHPEAKSRSGFLASAALKVLQQD

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8AR08

Antitoxin

Source ID Structure

References