Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1053974..1054644 Replicon chromosome
Accession NZ_CP124732
Organism Pseudomonas sp. GM17

Toxin (Protein)


Gene name vapC Uniprot ID A0A2N8BIG9
Locus tag PMI20_RS04710 Protein ID WP_007925281.1
Coordinates 1053974..1054402 (-) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A285EZ12
Locus tag PMI20_RS04715 Protein ID WP_007925278.1
Coordinates 1054399..1054644 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMI20_RS04685 (PMI20_004685) 1049702..1050442 - 741 WP_007925287.1 SDR family oxidoreductase -
PMI20_RS04690 (PMI20_004690) 1050581..1051471 + 891 WP_007925286.1 LysR family transcriptional regulator -
PMI20_RS04695 (PMI20_004695) 1051590..1051772 + 183 WP_007925285.1 type II toxin-antitoxin system HicA family toxin -
PMI20_RS04700 (PMI20_004700) 1051802..1052203 + 402 WP_009041686.1 type II toxin-antitoxin system HicB family antitoxin -
PMI20_RS04705 (PMI20_004705) 1052787..1053824 + 1038 WP_007925283.1 L-glyceraldehyde 3-phosphate reductase -
PMI20_RS04710 (PMI20_004710) 1053974..1054402 - 429 WP_007925281.1 type II toxin-antitoxin system VapC family toxin Toxin
PMI20_RS04715 (PMI20_004715) 1054399..1054644 - 246 WP_007925278.1 hypothetical protein Antitoxin
PMI20_RS04720 (PMI20_004720) 1054772..1055611 - 840 WP_007925276.1 taurine dioxygenase -
PMI20_RS04725 (PMI20_004725) 1055667..1056506 - 840 WP_007925274.1 taurine ABC transporter permease TauC -
PMI20_RS04730 (PMI20_004730) 1056503..1057297 - 795 WP_007925267.1 taurine ABC transporter ATP-binding subunit -
PMI20_RS04735 (PMI20_004735) 1057393..1058370 - 978 WP_007925265.1 taurine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15825.45 Da        Isoelectric Point: 5.4927

>T281125 WP_007925281.1 NZ_CP124732:c1054402-1053974 [Pseudomonas sp. GM17]
MIVLDTNVLSELMRPQPDASVLLWIEAQPVEDLYISAMTMAEILHGIARLPHGKRKQMLHASALAMFEEDFIDRIVPFGT
QAALYYAHLISHRESLGRPISLVDAQIAAICRVHDAAIATRNAKDFSDTGLIVINPWLPLEI

Download         Length: 429 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9072.30 Da        Isoelectric Point: 7.3226

>AT281125 WP_007925278.1 NZ_CP124732:c1054644-1054399 [Pseudomonas sp. GM17]
MASLTIRNLDDHIKERLRIEAAHNGHSMEEEARLILRRALSRTADSQGLASRIRARFAEAGGVKLELPERTEPARVVDLG
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2N8BIG9

Antitoxin

Source ID Structure
AlphaFold DB A0A285EZ12

References