281123

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 560309..562017 Replicon chromosome
Accession NZ_CP124732
Organism Pseudomonas sp. GM17

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag PMI20_RS02585 Protein ID WP_007928503.1
Coordinates 560309..561187 (+) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A5M7C4U8
Locus tag PMI20_RS02590 Protein ID WP_007928502.1
Coordinates 561184..562017 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PMI20_RS02560 (PMI20_002560) 556317..557153 + 837 WP_052034491.1 ABC transporter ATP-binding protein -
PMI20_RS02565 (PMI20_002565) 557193..558182 + 990 WP_007928507.1 ABC transporter substrate-binding protein -
PMI20_RS02570 (PMI20_002570) 558211..558987 + 777 WP_007928506.1 ABC transporter permease -
PMI20_RS02575 (PMI20_002575) 558987..559751 + 765 WP_007928505.1 SDR family oxidoreductase -
PMI20_RS02580 (PMI20_002580) 559765..560304 + 540 WP_007928504.1 cupin domain-containing protein -
PMI20_RS02585 (PMI20_002585) 560309..561187 + 879 WP_007928503.1 alpha/beta hydrolase Toxin
PMI20_RS02590 (PMI20_002590) 561184..562017 + 834 WP_007928502.1 IclR family transcriptional regulator Antitoxin
PMI20_RS02595 (PMI20_002595) 562019..562816 + 798 WP_007928501.1 SDR family oxidoreductase -
PMI20_RS02600 (PMI20_002600) 562809..564491 + 1683 WP_007928497.1 thiamine pyrophosphate-binding protein -
PMI20_RS02605 (PMI20_002605) 564502..565305 + 804 WP_007928496.1 aspartate dehydrogenase -
PMI20_RS02610 (PMI20_002610) 565317..566813 + 1497 WP_007928494.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(45-276)

Antitoxin

Transcription regulator IclR, C-terminal

(136-256)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 31014.61 Da        Isoelectric Point: 8.0027

>T281123 WP_007928503.1 NZ_CP124732:560309-561187 [Pseudomonas sp. GM17]
MLPGLSQPVSTADLQARLARDFAQRLVPVAGGRQALRECGAGPAIVLLHGIGSGAASWLQVARQLAPQARVIAWDAPGYG
DSSPLESPAPKAEHYAARLVQMLDALDVEECVLVGHSLGALPALAFARSSQASRVSRLLLISPARGYGAPERGEQRQQVR
RQRLENLEHLGIAGLAEQRSAHMLSPNAAPQALAWVRWNMARLNPAGYRQAIELLCGDDLLRHGQPGMPCEVHCGEADRI
TPAETCLTLAKALGASFNLIADAGHASPIEQPLVVAGRLAFAIKESLTGRTL

Download         Length: 879 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30869.31 Da        Isoelectric Point: 6.6493

>AT281123 WP_007928502.1 NZ_CP124732:561184-562017 [Pseudomonas sp. GM17]
MNDSDPLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRLNYPSNLVVRDGRSIVYVAKVSPPSVFSNAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQYSHSTPKTVLELFDMVQADRQRGFISGEGFFESAISTVAAPVRDQSGRIAAALGVTIPTTQIGHVNF
EELLSQVRRSADELSRLLNYNGVAHDGQQRVTALMRD

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5M7C4U8

References