Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 56424..57067 Replicon plasmid p3-KP21315
Accession NZ_CP124705
Organism Klebsiella pneumoniae strain KP21315

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag QJQ34_RS28210 Protein ID WP_087548942.1
Coordinates 56424..56840 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag QJQ34_RS28215 Protein ID WP_001261276.1
Coordinates 56837..57067 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ34_RS28190 (QJQ34_28190) 51600..52154 - 555 Protein_50 recombinase family protein -
QJQ34_RS28195 (QJQ34_28195) 52204..52908 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
QJQ34_RS28200 (QJQ34_28200) 53055..54578 - 1524 WP_087548941.1 EAL domain-containing protein -
QJQ34_RS28205 (QJQ34_28205) 55013..56240 - 1228 Protein_53 IS3 family transposase -
QJQ34_RS28210 (QJQ34_28210) 56424..56840 - 417 WP_087548942.1 type II toxin-antitoxin system VapC family toxin Toxin
QJQ34_RS28215 (QJQ34_28215) 56837..57067 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJQ34_RS28220 (QJQ34_28220) 57641..57991 + 351 WP_000493378.1 hypothetical protein -
QJQ34_RS28225 (QJQ34_28225) 58042..58785 + 744 WP_004098973.1 hypothetical protein -
QJQ34_RS28230 (QJQ34_28230) 58782..59558 + 777 WP_023302478.1 site-specific integrase -
QJQ34_RS28235 (QJQ34_28235) 59616..59873 - 258 WP_000764642.1 hypothetical protein -
QJQ34_RS28240 (QJQ34_28240) 60002..60106 - 105 WP_032410267.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaCTX-M-14 - 1..60640 60640


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15092.61 Da        Isoelectric Point: 8.5403

>T281122 WP_087548942.1 NZ_CP124705:c56840-56424 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNVREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT281122 WP_001261276.1 NZ_CP124705:c57067-56837 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References