281120

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 141274..141926 Replicon plasmid p1-KP21315
Accession NZ_CP124703
Organism Klebsiella pneumoniae strain KP21315

Toxin (Protein)


Gene name vagD Uniprot ID A0A8A2Q2K1
Locus tag QJQ34_RS26785 Protein ID WP_017901321.1
Coordinates 141274..141699 (-) Length 142 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID A0A853H7M9
Locus tag QJQ34_RS26790 Protein ID WP_001261275.1
Coordinates 141696..141926 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ34_RS26750 (QJQ34_26750) 136983..137099 + 117 Protein_150 transposase -
QJQ34_RS26755 (QJQ34_26755) 137224..137394 - 171 Protein_151 LysR family transcriptional regulator -
QJQ34_RS26760 (QJQ34_26760) 137405..137632 + 228 Protein_152 IS3 family transposase -
QJQ34_RS26765 (QJQ34_26765) 137724..139280 - 1557 WP_025999314.1 sensor domain-containing diguanylate cyclase -
QJQ34_RS26770 (QJQ34_26770) 139467..139640 - 174 Protein_154 nuclease -
QJQ34_RS26775 (QJQ34_26775) 139693..140229 - 537 Protein_155 integrase core domain-containing protein -
QJQ34_RS26780 (QJQ34_26780) 140288..141256 - 969 WP_102097429.1 IS5 family transposase -
QJQ34_RS26785 (QJQ34_26785) 141274..141699 - 426 WP_017901321.1 type II toxin-antitoxin system VapC family toxin Toxin
QJQ34_RS26790 (QJQ34_26790) 141696..141926 - 231 WP_001261275.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJQ34_RS26795 (QJQ34_26795) 142182..144758 - 2577 WP_017901322.1 nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid catA1 / tet(D) / blaSHV-12 - 1..254179 254179
- flank IS/Tn - - 140288..141256 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15412.91 Da        Isoelectric Point: 7.1364

>T281120 WP_017901321.1 NZ_CP124703:c141699-141274 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQVVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVGFVE

Download         Length: 426 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8707.72 Da        Isoelectric Point: 4.3410

>AT281120 WP_001261275.1 NZ_CP124703:c141926-141696 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFDP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8A2Q2K1

Antitoxin

Source ID Structure
AlphaFold DB A0A853H7M9

References