Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 68019..68929 | Replicon | plasmid p1-KP21315 |
| Accession | NZ_CP124703 | ||
| Organism | Klebsiella pneumoniae strain KP21315 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | R4YBC5 |
| Locus tag | QJQ34_RS26405 | Protein ID | WP_004144067.1 |
| Coordinates | 68459..68929 (+) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6A8PHD0 |
| Locus tag | QJQ34_RS26400 | Protein ID | WP_023287184.1 |
| Coordinates | 68019..68462 (+) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QJQ34_RS26380 (QJQ34_26380) | 63435..64184 | + | 750 | Protein_76 | IS5 family transposase | - |
| QJQ34_RS26385 (QJQ34_26385) | 64213..65181 | + | 969 | WP_000654811.1 | IS5 family transposase | - |
| QJQ34_RS26390 (QJQ34_26390) | 65377..66723 | + | 1347 | WP_227532884.1 | Mov34/MPN/PAD-1 family protein | - |
| QJQ34_RS26395 (QJQ34_26395) | 66776..67918 | + | 1143 | Protein_79 | translesion error-prone DNA polymerase V subunit UmuC | - |
| QJQ34_RS26400 (QJQ34_26400) | 68019..68462 | + | 444 | WP_023287184.1 | DUF2384 domain-containing protein | Antitoxin |
| QJQ34_RS26405 (QJQ34_26405) | 68459..68929 | + | 471 | WP_004144067.1 | RES family NAD+ phosphorylase | Toxin |
| QJQ34_RS26410 (QJQ34_26410) | 69016..70011 | + | 996 | WP_282499561.1 | IS5 family transposase | - |
| QJQ34_RS26415 (QJQ34_26415) | 70013..70981 | + | 969 | WP_072096747.1 | IS5 family transposase | - |
| QJQ34_RS26420 (QJQ34_26420) | 71170..71430 | - | 261 | WP_017901409.1 | hypothetical protein | - |
| QJQ34_RS26425 (QJQ34_26425) | 71735..72703 | + | 969 | WP_074423483.1 | IS5 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | catA1 / tet(D) / blaSHV-12 | - | 1..254179 | 254179 | |
| - | inside | IScluster/Tn | - | - | 61291..72703 | 11412 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17573.83 Da Isoelectric Point: 4.5152
>T281118 WP_004144067.1 NZ_CP124703:68459-68929 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16522.84 Da Isoelectric Point: 10.3013
>AT281118 WP_023287184.1 NZ_CP124703:68019-68462 [Klebsiella pneumoniae]
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSSPARPQRLWQVAGLNNADGVALLGQINEGLDGKVVNRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDREAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A384IED8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6A8PHD0 |