Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5207663..5208288 Replicon chromosome
Accession NZ_CP124702
Organism Klebsiella pneumoniae strain KP21315

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QJQ34_RS25635 Protein ID WP_002882817.1
Coordinates 5207663..5208046 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QJQ34_RS25640 Protein ID WP_004150355.1
Coordinates 5208046..5208288 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ34_RS25620 (5205029) 5205029..5205931 + 903 WP_282499306.1 formate dehydrogenase subunit beta -
QJQ34_RS25625 (5205928) 5205928..5206563 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QJQ34_RS25630 (5206560) 5206560..5207489 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QJQ34_RS25635 (5207663) 5207663..5208046 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QJQ34_RS25640 (5208046) 5208046..5208288 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QJQ34_RS25645 (5208493) 5208493..5209410 + 918 WP_023302328.1 alpha/beta hydrolase -
QJQ34_RS25650 (5209424) 5209424..5210365 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QJQ34_RS25655 (5210410) 5210410..5210847 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QJQ34_RS25660 (5210844) 5210844..5211704 - 861 WP_004146232.1 virulence factor BrkB family protein -
QJQ34_RS25665 (5211698) 5211698..5212297 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T281117 WP_002882817.1 NZ_CP124702:c5208046-5207663 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT281117 WP_004150355.1 NZ_CP124702:c5208288-5208046 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References