Detailed information of TA system TA281116

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4889287..4890968
• Replicon: chromosome
• Accession: NZ_CP124702
• Organism: Klebsiella pneumoniae strain KP21315

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: QJQ34_RS24180
• Protein ID: WP_200510127.1
• Coordinates: 4889287..4890204 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: QJQ34_RS24185
• Protein ID: WP_004177809.1
• Coordinates: 4890210..4890968 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJQ34_RS24160 (4884593)	4884593..4886113	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
QJQ34_RS24165 (4886110)	4886110..4887108	+	999	WP_012737175.1	ribose ABC transporter permease	-
QJQ34_RS24170 (4887139)	4887139..4888080	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
QJQ34_RS24175 (4888155)	4888155..4889162	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
QJQ34_RS24180 (4889287)	4889287..4890204	-	918	WP_200510127.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJQ34_RS24185 (4890210)	4890210..4890968	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
QJQ34_RS24190 (4891054)	4891054..4891782	-	729	WP_004177810.1	response regulator transcription factor	-
QJQ34_RS24195 (4892055)	4892055..4894202	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
QJQ34_RS24200 (4894432)	4894432..4895118	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T281116 WP_200510127.1 NZ_CP124702:c4890204-4889287 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVSLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT281116 WP_004177809.1 NZ_CP124702:c4890968-4890210 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05