Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4729782..4730298 Replicon chromosome
Accession NZ_CP124702
Organism Klebsiella pneumoniae strain KP21315

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag QJQ34_RS23380 Protein ID WP_002886902.1
Coordinates 4729782..4730066 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QJQ34_RS23385 Protein ID WP_002886901.1
Coordinates 4730056..4730298 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ34_RS23355 (4725198) 4725198..4725461 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
QJQ34_RS23360 (4725591) 4725591..4725764 + 174 WP_032410138.1 hypothetical protein -
QJQ34_RS23365 (4725767) 4725767..4726510 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
QJQ34_RS23370 (4726867) 4726867..4729005 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QJQ34_RS23375 (4729314) 4729314..4729778 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QJQ34_RS23380 (4729782) 4729782..4730066 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJQ34_RS23385 (4730056) 4730056..4730298 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QJQ34_RS23390 (4730376) 4730376..4732286 - 1911 WP_009486549.1 PRD domain-containing protein -
QJQ34_RS23395 (4732309) 4732309..4733463 - 1155 WP_023302389.1 lactonase family protein -
QJQ34_RS23400 (4733530) 4733530..4734270 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T281115 WP_002886902.1 NZ_CP124702:c4730066-4729782 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT281115 WP_002886901.1 NZ_CP124702:c4730298-4730056 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References