Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4635311..4636121 Replicon chromosome
Accession NZ_CP124702
Organism Klebsiella pneumoniae strain KP21315

Toxin (Protein)


Gene name KacT Uniprot ID A0A332NV98
Locus tag QJQ34_RS22965 Protein ID WP_014908042.1
Coordinates 4635311..4635844 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag QJQ34_RS22970 Protein ID WP_023343051.1
Coordinates 4635855..4636121 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ34_RS22960 (4634142) 4634142..4635263 + 1122 WP_012737335.1 cupin domain-containing protein -
QJQ34_RS22965 (4635311) 4635311..4635844 - 534 WP_014908042.1 type II toxin-antitoxin system toxin KacT Toxin
QJQ34_RS22970 (4635855) 4635855..4636121 - 267 WP_023343051.1 type II toxin-antitoxin system antitoxin KacA Antitoxin
QJQ34_RS22975 (4636224) 4636224..4637657 - 1434 WP_023343050.1 Cu(+)/Ag(+) sensor histidine kinase -
QJQ34_RS22980 (4637647) 4637647..4638330 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
QJQ34_RS22985 (4638503) 4638503..4639888 + 1386 WP_024623207.1 efflux transporter outer membrane subunit -
QJQ34_RS22990 (4639906) 4639906..4640250 + 345 WP_004192220.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19795.68 Da        Isoelectric Point: 5.2614

>T281114 WP_014908042.1 NZ_CP124702:c4635844-4635311 [Klebsiella pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGLGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10021.46 Da        Isoelectric Point: 10.5807

>AT281114 WP_023343051.1 NZ_CP124702:c4636121-4635855 [Klebsiella pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRRVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A332NV98

Antitoxin

Source ID Structure

References