281113

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4203402..4204108 Replicon chromosome
Accession NZ_CP124702
Organism Klebsiella pneumoniae strain KP21315

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag QJQ34_RS20920 Protein ID WP_024622903.1
Coordinates 4203740..4204108 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A485WAM6
Locus tag QJQ34_RS20915 Protein ID WP_023302278.1
Coordinates 4203402..4203719 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ34_RS20870 (4198543) 4198543..4199367 + 825 WP_023302271.1 DUF932 domain-containing protein -
QJQ34_RS20875 (4199576) 4199576..4200286 + 711 WP_023302272.1 DeoR family transcriptional regulator -
QJQ34_RS20880 (4200312) 4200312..4200848 + 537 WP_023302273.1 DUF4339 domain-containing protein -
QJQ34_RS20885 (4200890) 4200890..4201327 + 438 WP_023301392.1 hypothetical protein -
QJQ34_RS20890 (4201394) 4201394..4201804 + 411 WP_023302274.1 hypothetical protein -
QJQ34_RS20895 (4201882) 4201882..4202118 + 237 WP_032410024.1 DUF905 domain-containing protein -
QJQ34_RS20900 (4202205) 4202205..4202663 + 459 WP_023302275.1 antirestriction protein -
QJQ34_RS20905 (4202672) 4202672..4203154 + 483 WP_023302276.1 RadC family protein -
QJQ34_RS20910 (4203163) 4203163..4203384 + 222 WP_023302277.1 DUF987 domain-containing protein -
QJQ34_RS20915 (4203402) 4203402..4203719 + 318 WP_023302278.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
QJQ34_RS20920 (4203740) 4203740..4204108 + 369 WP_024622903.1 TA system toxin CbtA family protein Toxin
QJQ34_RS20925 (4204192) 4204192..4204446 + 255 WP_123618874.1 hypothetical protein -
QJQ34_RS20930 (4204569) 4204569..4207214 - 2646 WP_024622905.1 LuxR C-terminal-related transcriptional regulator -
QJQ34_RS20935 (4207588) 4207588..4208547 + 960 WP_023302280.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(4-104)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13651.82 Da        Isoelectric Point: 7.2897

>T281113 WP_024622903.1 NZ_CP124702:4203740-4204108 [Klebsiella pneumoniae]
MKNLPATISQAAKPCLSPVAVWQMLLTHLLEQHYGLMLSDTPFSDEAVIQEHIDAGITLANAVNFLVEKYELVRIDRCGF
SSQVQAPYLTATDILHARKACGLMSRYSYREVSNIVLSRSRI

Download         Length: 369 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11860.67 Da        Isoelectric Point: 6.4629

>AT281113 WP_023302278.1 NZ_CP124702:4203402-4203719 [Klebsiella pneumoniae]
MSNPTWGLLRDITPCLGARLVQEGNRLYYLVDRASITGKFSDAEILKLDVVFPHFISQMESMLTIGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYLTQR

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A485WAM6

References