Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PanAT/DUF4065(antitoxin) |
| Location | 3906281..3907254 | Replicon | chromosome |
| Accession | NZ_CP124702 | ||
| Organism | Klebsiella pneumoniae strain KP21315 | ||
Toxin (Protein)
| Gene name | panT | Uniprot ID | - |
| Locus tag | QJQ34_RS19300 | Protein ID | WP_072040111.1 |
| Coordinates | 3906847..3907254 (+) | Length | 136 a.a. |
Antitoxin (Protein)
| Gene name | panA | Uniprot ID | - |
| Locus tag | QJQ34_RS19295 | Protein ID | WP_040215292.1 |
| Coordinates | 3906281..3906850 (+) | Length | 190 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QJQ34_RS19260 (3902279) | 3902279..3902419 | - | 141 | WP_032409092.1 | hypothetical protein | - |
| QJQ34_RS19265 (3902744) | 3902744..3902914 | + | 171 | WP_002892370.1 | hypothetical protein | - |
| QJQ34_RS19270 (3902993) | 3902993..3903394 | - | 402 | WP_023302224.1 | hydroxyisourate hydrolase | - |
| QJQ34_RS19275 (3903790) | 3903790..3904083 | - | 294 | WP_002892360.1 | hypothetical protein | - |
| QJQ34_RS19280 (3905025) | 3905025..3905417 | - | 393 | WP_052455502.1 | KilA-N domain-containing protein | - |
| QJQ34_RS19285 (3905500) | 3905500..3905748 | + | 249 | WP_032410641.1 | AlpA family phage regulatory protein | - |
| QJQ34_RS19290 (3905849) | 3905849..3906112 | + | 264 | WP_267696096.1 | hypothetical protein | - |
| QJQ34_RS19295 (3906281) | 3906281..3906850 | + | 570 | WP_040215292.1 | Panacea domain-containing protein | Antitoxin |
| QJQ34_RS19300 (3906847) | 3906847..3907254 | + | 408 | WP_072040111.1 | hypothetical protein | Toxin |
| QJQ34_RS19305 (3907287) | 3907287..3907670 | - | 384 | WP_040215289.1 | Rap1a/Tai family immunity protein | - |
| QJQ34_RS19310 (3907673) | 3907673..3909205 | - | 1533 | WP_267696097.1 | hypothetical protein | - |
| QJQ34_RS19320 (3910497) | 3910497..3911465 | - | 969 | WP_267696098.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3905849..3990518 | 84669 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15154.21 Da Isoelectric Point: 5.9868
>T281111 WP_072040111.1 NZ_CP124702:3906847-3907254 [Klebsiella pneumoniae]
MTQQYAPYRKGTVLAPVGGSDHLHIICNDPVHYPIHGCDCVLVVNISSVYPPPAYSDPACILHAGEHPFVFHDSFVYYED
AIVWKVPNVISREQSGELTPHADMEENVLQRVLSGFEASDFTNPKILKFYRAHCI
MTQQYAPYRKGTVLAPVGGSDHLHIICNDPVHYPIHGCDCVLVVNISSVYPPPAYSDPACILHAGEHPFVFHDSFVYYED
AIVWKVPNVISREQSGELTPHADMEENVLQRVLSGFEASDFTNPKILKFYRAHCI
Download Length: 408 bp
Antitoxin
Download Length: 190 a.a. Molecular weight: 21591.42 Da Isoelectric Point: 4.9915
>AT281111 WP_040215292.1 NZ_CP124702:3906281-3906850 [Klebsiella pneumoniae]
MYSESKTAQMAGYLLLKRGGRMAYIKLMKLLYLADREYMITYGDSMTGDRAVSMNNGPVLSRTYDLLKSGSPEEESPWDD
WIAGEADFEVSLKKRVNGLDDDDAFDELSKANKRILDKVFDEYGQYKRFELCDLTHRVCAEWQNPHGSSVPISPKDILMA
GGKSESEADELIRHMRERDALKQFSRQLA
MYSESKTAQMAGYLLLKRGGRMAYIKLMKLLYLADREYMITYGDSMTGDRAVSMNNGPVLSRTYDLLKSGSPEEESPWDD
WIAGEADFEVSLKKRVNGLDDDDAFDELSKANKRILDKVFDEYGQYKRFELCDLTHRVCAEWQNPHGSSVPISPKDILMA
GGKSESEADELIRHMRERDALKQFSRQLA
Download Length: 570 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|