28111

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3183148..3183835 Replicon chromosome
Accession NC_018143
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name vapC Uniprot ID P65044
Locus tag RVBD_RS15170 Protein ID WP_003414624.1
Coordinates 3183392..3183835 (+) Length 148 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID G0TFH0
Locus tag RVBD_RS15165 Protein ID WP_003414620.1
Coordinates 3183148..3183405 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVBD_RS15145 3178468..3179322 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
RVBD_RS15150 3179378..3180541 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
RVBD_RS15155 3180558..3181772 - 1215 WP_003899518.1 zinc metalloprotease Rip -
RVBD_RS15160 3181780..3183021 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -
RVBD_RS15165 3183148..3183405 + 258 WP_003414620.1 ribbon-helix-helix domain-containing protein Antitoxin
RVBD_RS15170 3183392..3183835 + 444 WP_003414624.1 type II toxin-antitoxin system VapC family toxin Toxin
RVBD_RS15175 3183915..3184577 + 663 WP_003414630.1 cell surface glycolipoprotein Mpt83 -
RVBD_RS15180 3184673..3184864 + 192 WP_003414632.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
RVBD_RS15185 3185196..3186944 + 1749 WP_178121166.1 cytochrome c biogenesis protein DipZ -
RVBD_RS15190 3187040..3187621 + 582 WP_003414644.1 fasciclin domain-containing protein -
RVBD_RS15195 3187721..3187987 + 267 WP_015456449.1 DUF2631 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-142)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 148 a.a.        Molecular weight: 16595.72 Da        Isoelectric Point: 6.4890

>T28111 WP_003414624.1 NC_018143:3183392-3183835 [Mycobacterium tuberculosis H37Rv]
MLCVDVNVLVYAHRADLREHADYRGLLERLANDDEPLGLPDSVLAGFIRVVTNRRVFTEPTSPQDAWQAVDALLAAPAAM
RLRPGERHWMAFRQLASDVDANGNDIADAHLAAYALENNATWLSADRGFARFRRLRWRHPLDGQTHL

Download         Length: 444 bp

>T28111 NC_018143:3183392-3183835 [Mycobacterium tuberculosis H37Rv]
ATGCTGTGCGTTGATGTCAACGTGCTCGTTTACGCGCATCGGGCAGACCTACGGGAGCACGCGGACTATCGGGGTTTGCT
TGAGCGGCTGGCCAACGATGACGAGCCGCTGGGTCTACCAGATAGCGTGCTCGCCGGCTTCATCCGGGTGGTTACCAACC
GCCGCGTCTTCACCGAGCCGACGAGCCCACAGGACGCATGGCAGGCAGTCGACGCCCTACTCGCGGCACCCGCAGCCATG
CGACTTCGGCCTGGCGAGCGCCACTGGATGGCCTTTCGGCAGTTAGCGTCCGATGTTGATGCGAACGGCAACGACATTGC
GGACGCGCACCTGGCCGCCTACGCGCTAGAGAACAACGCAACCTGGTTGAGCGCCGACCGCGGCTTTGCCCGTTTCCGTC
GACTGCGCTGGCGTCATCCGTTGGACGGTCAGACCCATCTATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9013.22 Da        Isoelectric Point: 10.8344

>AT28111 WP_003414620.1 NC_018143:3183148-3183405 [Mycobacterium tuberculosis H37Rv]
VRTTIRIDDELYREVKAKAARSGRTVAAVLEDAVRRGLNPPKPQAAGRYRVQPSGKGGLRPGVDLSSNAALAEAMNDGVS
VDAVR

Download         Length: 258 bp

>AT28111 NC_018143:3183148-3183405 [Mycobacterium tuberculosis H37Rv]
GTGCGCACGACGATCCGTATCGATGACGAGCTGTACCGCGAGGTGAAAGCAAAGGCCGCTCGTTCCGGGCGTACCGTGGC
CGCGGTTCTTGAAGATGCGGTGCGGCGTGGTCTCAACCCGCCTAAGCCGCAGGCCGCCGGCCGTTATCGAGTCCAGCCGT
CGGGTAAGGGCGGCCTGCGGCCCGGTGTCGATCTATCGTCCAACGCCGCACTTGCCGAAGCGATGAACGACGGCGTGTCG
GTCGATGCTGTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VWO

Antitoxin

Source ID Structure
PDB 7VWO
AlphaFold DB G0TFH0

References