Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 790054..790711 Replicon chromosome
Accession NZ_CP124702
Organism Klebsiella pneumoniae strain KP21315

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QJQ34_RS03935 Protein ID WP_002916310.1
Coordinates 790301..790711 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QJQ34_RS03930 Protein ID WP_002916312.1
Coordinates 790054..790320 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ34_RS03905 (785210) 785210..786643 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
QJQ34_RS03910 (786762) 786762..787490 - 729 WP_023342613.1 MurR/RpiR family transcriptional regulator -
QJQ34_RS03915 (787540) 787540..787851 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QJQ34_RS03920 (788015) 788015..788674 + 660 WP_002916317.1 hemolysin III family protein -
QJQ34_RS03925 (788825) 788825..789808 - 984 WP_023342614.1 tRNA-modifying protein YgfZ -
QJQ34_RS03930 (790054) 790054..790320 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QJQ34_RS03935 (790301) 790301..790711 + 411 WP_002916310.1 protein YgfX Toxin
QJQ34_RS03940 (790718) 790718..791239 - 522 WP_002916308.1 flavodoxin FldB -
QJQ34_RS03945 (791340) 791340..792236 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QJQ34_RS03950 (792259) 792259..792972 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJQ34_RS03955 (792978) 792978..794711 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T281105 WP_002916310.1 NZ_CP124702:790301-790711 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT281105 WP_002916312.1 NZ_CP124702:790054-790320 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References