Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 15538..16063 Replicon plasmid p2-KP21317
Accession NZ_CP124700
Organism Klebsiella pneumoniae strain KP21317

Toxin (Protein)


Gene name ccdB Uniprot ID D4HQE7
Locus tag QJQ33_RS27560 Protein ID WP_013023785.1
Coordinates 15758..16063 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag QJQ33_RS27555 Protein ID WP_001568025.1
Coordinates 15538..15756 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ33_RS27535 (QJQ33_27535) 10694..11473 + 780 WP_013023780.1 hypothetical protein -
QJQ33_RS27540 (QJQ33_27540) 11680..13272 + 1593 WP_015344964.1 hypothetical protein -
QJQ33_RS27545 (QJQ33_27545) 13306..14433 + 1128 WP_013023782.1 DUF4238 domain-containing protein -
QJQ33_RS27550 (QJQ33_27550) 14430..14720 + 291 WP_013023783.1 hypothetical protein -
QJQ33_RS27555 (QJQ33_27555) 15538..15756 + 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
QJQ33_RS27560 (QJQ33_27560) 15758..16063 + 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB Toxin
QJQ33_RS27565 (QJQ33_27565) 16232..16627 + 396 WP_017899885.1 hypothetical protein -
QJQ33_RS27570 (QJQ33_27570) 16654..16968 + 315 WP_053389906.1 hypothetical protein -
QJQ33_RS27575 (QJQ33_27575) 16979..17995 + 1017 WP_017899884.1 hypothetical protein -
QJQ33_RS27580 (QJQ33_27580) 18193..18987 + 795 WP_004197635.1 site-specific integrase -
QJQ33_RS27585 (QJQ33_27585) 19419..19721 - 303 WP_004197636.1 hypothetical protein -
QJQ33_RS27590 (QJQ33_27590) 19718..20344 - 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / blaTEM-1B - 1..93119 93119


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11615.30 Da        Isoelectric Point: 6.4672

>T281102 WP_013023785.1 NZ_CP124700:15758-16063 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT281102 WP_001568025.1 NZ_CP124700:15538-15756 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References