Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 49203..49939 Replicon plasmid p1-KP21317
Accession NZ_CP124699
Organism Klebsiella pneumoniae strain KP21317

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag QJQ33_RS26910 Protein ID WP_003026803.1
Coordinates 49457..49939 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag QJQ33_RS26905 Protein ID WP_003026799.1
Coordinates 49203..49469 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ33_RS26885 (QJQ33_26885) 44938..45156 - 219 Protein_44 transposase -
QJQ33_RS26890 (QJQ33_26890) 45369..45878 + 510 WP_049183345.1 SMI1/KNR4 family protein -
QJQ33_RS26895 (QJQ33_26895) 45901..47568 + 1668 WP_049183348.1 hypothetical protein -
QJQ33_RS26900 (QJQ33_26900) 47582..48781 + 1200 WP_013609503.1 hypothetical protein -
QJQ33_RS26905 (QJQ33_26905) 49203..49469 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
QJQ33_RS26910 (QJQ33_26910) 49457..49939 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
QJQ33_RS26915 (QJQ33_26915) 50140..51543 + 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
QJQ33_RS26920 (QJQ33_26920) 51572..52204 - 633 WP_059689567.1 hypothetical protein -
QJQ33_RS26925 (QJQ33_26925) 52381..53546 - 1166 Protein_52 IS3 family transposase -
QJQ33_RS26930 (QJQ33_26930) 53723..54685 - 963 WP_004152113.1 zinc metalloprotease HtpX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..144264 144264
- inside IScluster/Tn - - 41847..53408 11561


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T281101 WP_003026803.1 NZ_CP124699:49457-49939 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT281101 WP_003026799.1 NZ_CP124699:49203-49469 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References