Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5407570..5408195 Replicon chromosome
Accession NZ_CP124698
Organism Klebsiella pneumoniae strain KP21317

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QJQ33_RS26300 Protein ID WP_002882817.1
Coordinates 5407570..5407953 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QJQ33_RS26305 Protein ID WP_004150355.1
Coordinates 5407953..5408195 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ33_RS26285 (5404936) 5404936..5405838 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QJQ33_RS26290 (5405835) 5405835..5406470 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QJQ33_RS26295 (5406467) 5406467..5407396 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QJQ33_RS26300 (5407570) 5407570..5407953 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QJQ33_RS26305 (5407953) 5407953..5408195 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QJQ33_RS26310 (5408400) 5408400..5409317 + 918 WP_004181612.1 alpha/beta hydrolase -
QJQ33_RS26315 (5409331) 5409331..5410272 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QJQ33_RS26320 (5410317) 5410317..5410754 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QJQ33_RS26325 (5410751) 5410751..5411611 - 861 WP_004146232.1 virulence factor BrkB family protein -
QJQ33_RS26330 (5411605) 5411605..5412204 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T281099 WP_002882817.1 NZ_CP124698:c5407953-5407570 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT281099 WP_004150355.1 NZ_CP124698:c5408195-5407953 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References