Detailed information of TA system TA281098

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5094815..5096496
• Replicon: chromosome
• Accession: NZ_CP124698
• Organism: Klebsiella pneumoniae strain KP21317

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: QJQ33_RS24865
• Protein ID: WP_004178299.1
• Coordinates: 5094815..5095732 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: QJQ33_RS24870
• Protein ID: WP_004177809.1
• Coordinates: 5095738..5096496 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QJQ33_RS24845 (5090121)	5090121..5091641	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
QJQ33_RS24850 (5091638)	5091638..5092636	+	999	WP_002885172.1	ribose ABC transporter permease	-
QJQ33_RS24855 (5092667)	5092667..5093608	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
QJQ33_RS24860 (5093683)	5093683..5094690	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
QJQ33_RS24865 (5094815)	5094815..5095732	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
QJQ33_RS24870 (5095738)	5095738..5096496	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
QJQ33_RS24875 (5096582)	5096582..5097310	-	729	WP_004178298.1	response regulator transcription factor	-
QJQ33_RS24880 (5097583)	5097583..5099730	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
QJQ33_RS24885 (5099960)	5099960..5100646	+	687	WP_004151733.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T281098 WP_004178299.1 NZ_CP124698:c5095732-5094815 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT281098 WP_004177809.1 NZ_CP124698:c5096496-5095738 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

Structures

Antitoxin

• AlphaFold DB: A6TH05