Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4939120..4939636 Replicon chromosome
Accession NZ_CP124698
Organism Klebsiella pneumoniae strain KP21317

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag QJQ33_RS24070 Protein ID WP_004178374.1
Coordinates 4939120..4939404 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag QJQ33_RS24075 Protein ID WP_002886901.1
Coordinates 4939394..4939636 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ33_RS24045 (4934604) 4934604..4934867 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
QJQ33_RS24050 (4934997) 4934997..4935170 + 174 WP_032408826.1 hypothetical protein -
QJQ33_RS24055 (4935173) 4935173..4935916 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
QJQ33_RS24060 (4936273) 4936273..4938411 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
QJQ33_RS24065 (4938652) 4938652..4939116 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
QJQ33_RS24070 (4939120) 4939120..4939404 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJQ33_RS24075 (4939394) 4939394..4939636 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
QJQ33_RS24080 (4939714) 4939714..4941624 - 1911 WP_004178373.1 PRD domain-containing protein -
QJQ33_RS24085 (4941647) 4941647..4942801 - 1155 WP_004178372.1 lactonase family protein -
QJQ33_RS24090 (4942868) 4942868..4943608 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T281097 WP_004178374.1 NZ_CP124698:c4939404-4939120 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT281097 WP_002886901.1 NZ_CP124698:c4939636-4939394 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References