Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2755258..2756846 Replicon chromosome
Accession NZ_CP124698
Organism Klebsiella pneumoniae strain KP21317

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QJQ33_RS13515 Protein ID WP_004179815.1
Coordinates 2755258..2756580 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QJQ33_RS13520 Protein ID WP_004176198.1
Coordinates 2756580..2756846 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ33_RS13500 (2750314) 2750314..2752815 + 2502 WP_004179823.1 fimbria/pilus outer membrane usher protein -
QJQ33_RS13505 (2752803) 2752803..2753807 + 1005 WP_004179822.1 fimbrial protein -
QJQ33_RS13510 (2753949) 2753949..2755241 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QJQ33_RS13515 (2755258) 2755258..2756580 - 1323 WP_004179815.1 type II toxin-antitoxin system HipA family toxin Toxin
QJQ33_RS13520 (2756580) 2756580..2756846 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QJQ33_RS13525 (2757112) 2757112..2757438 - 327 WP_002904788.1 hydroxyisourate hydrolase -
QJQ33_RS13530 (2757435) 2757435..2757935 - 501 WP_004179811.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QJQ33_RS13535 (2757913) 2757913..2759292 - 1380 WP_004179808.1 nucleobase:cation symporter-2 family protein -
QJQ33_RS13540 (2759638) 2759638..2760792 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QJQ33_RS13545 (2760773) 2760773..2761696 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49152.42 Da        Isoelectric Point: 7.2850

>T281092 WP_004179815.1 NZ_CP124698:c2756580-2755258 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT281092 WP_004176198.1 NZ_CP124698:c2756846-2756580 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References