Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 791177..791834 Replicon chromosome
Accession NZ_CP124698
Organism Klebsiella pneumoniae strain KP21317

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag QJQ33_RS03910 Protein ID WP_004181233.1
Coordinates 791424..791834 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QJQ33_RS03905 Protein ID WP_002916312.1
Coordinates 791177..791443 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ33_RS03880 (786333) 786333..787766 - 1434 WP_004181234.1 6-phospho-beta-glucosidase -
QJQ33_RS03885 (787885) 787885..788613 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QJQ33_RS03890 (788663) 788663..788974 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QJQ33_RS03895 (789138) 789138..789797 + 660 WP_002916317.1 hemolysin III family protein -
QJQ33_RS03900 (789948) 789948..790931 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QJQ33_RS03905 (791177) 791177..791443 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QJQ33_RS03910 (791424) 791424..791834 + 411 WP_004181233.1 protein YgfX Toxin
QJQ33_RS03915 (791841) 791841..792362 - 522 WP_004144730.1 flavodoxin FldB -
QJQ33_RS03920 (792463) 792463..793359 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QJQ33_RS03925 (793382) 793382..794095 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJQ33_RS03930 (794101) 794101..795834 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16121.92 Da        Isoelectric Point: 11.1565

>T281087 WP_004181233.1 NZ_CP124698:791424-791834 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT281087 WP_002916312.1 NZ_CP124698:791177-791443 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References