Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 21208..21851 Replicon plasmid p4-KP21300
Accession NZ_CP124697
Organism Klebsiella pneumoniae strain KP21300

Toxin (Protein)


Gene name vagD Uniprot ID A0A7D6UII7
Locus tag QJQ26_RS28750 Protein ID WP_032425563.1
Coordinates 21208..21624 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag QJQ26_RS28755 Protein ID WP_001261276.1
Coordinates 21621..21851 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ26_RS28735 (QJQ26_28735) 16252..18360 - 2109 WP_214603304.1 peptidase domain-containing ABC transporter -
QJQ26_RS28740 (QJQ26_28740) 18350..19627 - 1278 WP_009309915.1 HlyD family secretion protein -
QJQ26_RS28745 (QJQ26_28745) 20289..21167 + 879 WP_064182004.1 restriction endonuclease -
QJQ26_RS28750 (QJQ26_28750) 21208..21624 - 417 WP_032425563.1 type II toxin-antitoxin system VapC family toxin Toxin
QJQ26_RS28755 (QJQ26_28755) 21621..21851 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
QJQ26_RS28760 (QJQ26_28760) 22422..22772 + 351 WP_000493378.1 hypothetical protein -
QJQ26_RS28765 (QJQ26_28765) 22823..23566 + 744 WP_000129823.1 hypothetical protein -
QJQ26_RS28770 (QJQ26_28770) 23563..24339 + 777 WP_000015958.1 site-specific integrase -
QJQ26_RS28775 (QJQ26_28775) 24397..24654 - 258 WP_000764642.1 hypothetical protein -
QJQ26_RS28780 (QJQ26_28780) 24783..24887 - 105 WP_032409716.1 hypothetical protein -
QJQ26_RS28785 (QJQ26_28785) 25422..26288 + 867 WP_004118283.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid qnrS1 / dfrA14 / tet(D) - 1..62484 62484


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15080.56 Da        Isoelectric Point: 8.5403

>T281085 WP_032425563.1 NZ_CP124697:c21624-21208 [Klebsiella pneumoniae]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAILPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPGLVLEDWVK

Download         Length: 417 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT281085 WP_001261276.1 NZ_CP124697:c21851-21621 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D6UII7

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References