Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 15450..15975 Replicon plasmid p3-KP21300
Accession NZ_CP124696
Organism Klebsiella pneumoniae strain KP21300

Toxin (Protein)


Gene name ccdB Uniprot ID D4HQE7
Locus tag QJQ26_RS28115 Protein ID WP_013023785.1
Coordinates 15670..15975 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID W8V2V6
Locus tag QJQ26_RS28110 Protein ID WP_001568025.1
Coordinates 15450..15668 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ26_RS28090 (QJQ26_28090) 10606..11385 + 780 WP_013023780.1 hypothetical protein -
QJQ26_RS28095 (QJQ26_28095) 11661..13184 + 1524 WP_017899887.1 hypothetical protein -
QJQ26_RS28100 (QJQ26_28100) 13218..14345 + 1128 WP_013023782.1 DUF4238 domain-containing protein -
QJQ26_RS28105 (QJQ26_28105) 14342..14632 + 291 WP_013023783.1 hypothetical protein -
QJQ26_RS28110 (QJQ26_28110) 15450..15668 + 219 WP_001568025.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
QJQ26_RS28115 (QJQ26_28115) 15670..15975 + 306 WP_013023785.1 type II toxin-antitoxin system toxin CcdB Toxin
QJQ26_RS28120 (QJQ26_28120) 16144..16539 + 396 WP_017899885.1 hypothetical protein -
QJQ26_RS28125 (QJQ26_28125) 16566..16880 + 315 WP_053389906.1 hypothetical protein -
QJQ26_RS28130 (QJQ26_28130) 16891..17907 + 1017 WP_017899884.1 hypothetical protein -
QJQ26_RS28135 (QJQ26_28135) 18105..18899 + 795 WP_004197635.1 site-specific integrase -
QJQ26_RS28140 (QJQ26_28140) 19331..19633 - 303 WP_004197636.1 hypothetical protein -
QJQ26_RS28145 (QJQ26_28145) 19630..20256 - 627 WP_004197649.1 ParA family plasmid-partitioning AAA ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-15 / blaTEM-1B - 1..96675 96675


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11615.30 Da        Isoelectric Point: 6.4672

>T281083 WP_013023785.1 NZ_CP124696:15670-15975 [Klebsiella pneumoniae]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8392.34 Da        Isoelectric Point: 4.7405

>AT281083 WP_001568025.1 NZ_CP124696:15450-15668 [Klebsiella pneumoniae]
MKQRITVTIDSDSYQLLKSADVNISALVNRAMQNEARRLRSERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J4ZZW6

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZZP8

References