Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5184501..5185126 Replicon chromosome
Accession NZ_CP124693
Organism Klebsiella pneumoniae strain KP21300

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag QJQ26_RS25270 Protein ID WP_002882817.1
Coordinates 5184501..5184884 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag QJQ26_RS25275 Protein ID WP_004150355.1
Coordinates 5184884..5185126 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ26_RS25255 (5181867) 5181867..5182769 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
QJQ26_RS25260 (5182766) 5182766..5183401 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
QJQ26_RS25265 (5183398) 5183398..5184327 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
QJQ26_RS25270 (5184501) 5184501..5184884 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
QJQ26_RS25275 (5184884) 5184884..5185126 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
QJQ26_RS25280 (5185331) 5185331..5186248 + 918 WP_032418237.1 alpha/beta hydrolase -
QJQ26_RS25285 (5186262) 5186262..5187203 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
QJQ26_RS25290 (5187248) 5187248..5187685 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
QJQ26_RS25295 (5187682) 5187682..5188542 - 861 WP_004146232.1 virulence factor BrkB family protein -
QJQ26_RS25300 (5188536) 5188536..5189135 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T281081 WP_002882817.1 NZ_CP124693:c5184884-5184501 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT281081 WP_004150355.1 NZ_CP124693:c5185126-5184884 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References