Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2620953..2622541 Replicon chromosome
Accession NZ_CP124693
Organism Klebsiella pneumoniae strain KP21300

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag QJQ26_RS12965 Protein ID WP_004184027.1
Coordinates 2620953..2622275 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag QJQ26_RS12970 Protein ID WP_004176198.1
Coordinates 2622275..2622541 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ26_RS12950 (2616009) 2616009..2618510 + 2502 WP_032439971.1 fimbria/pilus outer membrane usher protein -
QJQ26_RS12955 (2618498) 2618498..2619502 + 1005 WP_016946380.1 fimbrial protein -
QJQ26_RS12960 (2619644) 2619644..2620936 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
QJQ26_RS12965 (2620953) 2620953..2622275 - 1323 WP_004184027.1 type II toxin-antitoxin system HipA family toxin Toxin
QJQ26_RS12970 (2622275) 2622275..2622541 - 267 WP_004176198.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
QJQ26_RS12975 (2622807) 2622807..2623133 - 327 WP_004215084.1 hydroxyisourate hydrolase -
QJQ26_RS12980 (2623130) 2623130..2623630 - 501 WP_032418978.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
QJQ26_RS12985 (2623608) 2623608..2624987 - 1380 WP_004184021.1 nucleobase:cation symporter-2 family protein -
QJQ26_RS12990 (2625333) 2625333..2626487 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
QJQ26_RS12995 (2626468) 2626468..2627391 - 924 WP_032418980.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49139.47 Da        Isoelectric Point: 7.5367

>T281076 WP_004184027.1 NZ_CP124693:c2622275-2620953 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYEEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.36 Da        Isoelectric Point: 8.5912

>AT281076 WP_004176198.1 NZ_CP124693:c2622541-2622275 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References