Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1812261..1812851 Replicon chromosome
Accession NZ_CP124693
Organism Klebsiella pneumoniae strain KP21300

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag QJQ26_RS08870 Protein ID WP_023341911.1
Coordinates 1812519..1812851 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A3S7DDD0
Locus tag QJQ26_RS08865 Protein ID WP_000288812.1
Coordinates 1812261..1812518 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ26_RS08840 (1808171) 1808171..1808245 + 75 Protein_1732 type II toxin-antitoxin system PemK/MazF family toxin -
QJQ26_RS08845 (1808596) 1808596..1810344 + 1749 WP_032418698.1 hypothetical protein -
QJQ26_RS08850 (1810398) 1810398..1810979 + 582 WP_099184326.1 hypothetical protein -
QJQ26_RS08855 (1811262) 1811262..1811723 + 462 WP_004213450.1 hypothetical protein -
QJQ26_RS08860 (1811720) 1811720..1811926 + 207 WP_020805021.1 helix-turn-helix transcriptional regulator -
QJQ26_RS08865 (1812261) 1812261..1812518 + 258 WP_000288812.1 antitoxin Antitoxin
QJQ26_RS08870 (1812519) 1812519..1812851 + 333 WP_023341911.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
QJQ26_RS08880 (1813173) 1813173..1814609 + 1437 WP_004151469.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
QJQ26_RS08890 (1814975) 1814975..1816429 - 1455 WP_004148975.1 AMP nucleosidase -
QJQ26_RS08895 (1816559) 1816559..1816804 - 246 WP_004141189.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11927.87 Da        Isoelectric Point: 10.4722

>T281071 WP_023341911.1 NZ_CP124693:1812519-1812851 [Klebsiella pneumoniae]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARKGKRLERIPDVVVNEVLARLDAMLS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9442.92 Da        Isoelectric Point: 4.3566

>AT281071 WP_000288812.1 NZ_CP124693:1812261-1812518 [Klebsiella pneumoniae]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S7DDD0

References