Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 801370..802027 Replicon chromosome
Accession NZ_CP124693
Organism Klebsiella pneumoniae strain KP21300

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag QJQ26_RS03990 Protein ID WP_002916310.1
Coordinates 801617..802027 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag QJQ26_RS03985 Protein ID WP_002916312.1
Coordinates 801370..801636 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJQ26_RS03960 (796526) 796526..797959 - 1434 WP_032418366.1 6-phospho-beta-glucosidase -
QJQ26_RS03965 (798078) 798078..798806 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
QJQ26_RS03970 (798856) 798856..799167 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
QJQ26_RS03975 (799331) 799331..799990 + 660 WP_002916317.1 hemolysin III family protein -
QJQ26_RS03980 (800141) 800141..801124 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
QJQ26_RS03985 (801370) 801370..801636 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
QJQ26_RS03990 (801617) 801617..802027 + 411 WP_002916310.1 protein YgfX Toxin
QJQ26_RS03995 (802034) 802034..802555 - 522 WP_004144730.1 flavodoxin FldB -
QJQ26_RS04000 (802656) 802656..803552 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
QJQ26_RS04005 (803575) 803575..804288 + 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
QJQ26_RS04010 (804294) 804294..806027 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T281070 WP_002916310.1 NZ_CP124693:801617-802027 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT281070 WP_002916312.1 NZ_CP124693:801370-801636 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References