281061

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4389822..4391080 Replicon chromosome
Accession NZ_CP124670
Organism Pseudomonas aeruginosa strain 2021CK-01536

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QJ974_RS20265 Protein ID WP_003163133.1
Coordinates 4389822..4390577 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QJ974_RS20270 Protein ID WP_003086329.1
Coordinates 4390712..4391080 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ974_RS20255 (QJ974_20255) 4384994..4387537 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
QJ974_RS20260 (QJ974_20260) 4387692..4389053 - 1362 WP_079262974.1 DNA recombination protein RmuC -
QJ974_RS20265 (QJ974_20265) 4389822..4390577 - 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
QJ974_RS20270 (QJ974_20270) 4390712..4391080 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QJ974_RS20275 (QJ974_20275) 4391153..4392439 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
QJ974_RS20280 (QJ974_20280) 4392495..4393988 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
QJ974_RS20285 (QJ974_20285) 4394163..4394639 + 477 WP_003112531.1 hypothetical protein -
QJ974_RS20290 (QJ974_20290) 4394642..4394917 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T281061 WP_003163133.1 NZ_CP124670:c4390577-4389822 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT281061 WP_003086329.1 NZ_CP124670:c4391080-4390712 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References