Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3468084..3469305 Replicon chromosome
Accession NZ_CP124670
Organism Pseudomonas aeruginosa strain 2021CK-01536

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag QJ974_RS15930 Protein ID WP_003102740.1
Coordinates 3468727..3469305 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QJ974_RS15925 Protein ID WP_003088112.1
Coordinates 3468084..3468638 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ974_RS15900 (QJ974_15900) 3463652..3464203 + 552 WP_003132721.1 XRE family transcriptional regulator -
QJ974_RS15905 (QJ974_15905) 3464200..3464598 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
QJ974_RS15910 (QJ974_15910) 3464611..3464934 - 324 WP_003102734.1 multidrug efflux SMR transporter -
QJ974_RS15915 (QJ974_15915) 3465265..3465726 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
QJ974_RS15920 (QJ974_15920) 3465731..3467926 + 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
QJ974_RS15925 (QJ974_15925) 3468084..3468638 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
QJ974_RS15930 (QJ974_15930) 3468727..3469305 + 579 WP_003102740.1 HD domain-containing protein Toxin
QJ974_RS15935 (QJ974_15935) 3469413..3470600 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
QJ974_RS15940 (QJ974_15940) 3470590..3472761 - 2172 WP_014603035.1 type I secretion system permease/ATPase -
QJ974_RS15945 (QJ974_15945) 3472751..3474028 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T281060 WP_003102740.1 NZ_CP124670:3468727-3469305 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT281060 WP_003088112.1 NZ_CP124670:3468084-3468638 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References