281059

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1820073..1821581 Replicon chromosome
Accession NZ_CP124670
Organism Pseudomonas aeruginosa strain 2021CK-01536

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QJ974_RS08515 Protein ID WP_012613851.1
Coordinates 1820073..1820660 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9HYX2
Locus tag QJ974_RS08520 Protein ID WP_003115566.1
Coordinates 1820727..1821581 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ974_RS08510 (QJ974_08510) 1816328..1819807 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
QJ974_RS08515 (QJ974_08515) 1820073..1820660 + 588 WP_012613851.1 GNAT family protein Toxin
QJ974_RS08520 (QJ974_08520) 1820727..1821581 + 855 WP_003115566.1 AraC family transcriptional regulator Antitoxin
QJ974_RS08525 (QJ974_08525) 1821678..1823843 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
QJ974_RS08530 (QJ974_08530) 1824018..1825892 + 1875 WP_014602678.1 MFS transporter -
QJ974_RS08535 (QJ974_08535) 1825953..1826162 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T281059 WP_012613851.1 NZ_CP124670:1820073-1820660 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31933.23 Da        Isoelectric Point: 7.3276

>AT281059 WP_003115566.1 NZ_CP124670:1820727-1821581 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYX2

References