281058

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 141541..142046 Replicon chromosome
Accession NZ_CP124670
Organism Pseudomonas aeruginosa strain 2021CK-01536

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag QJ974_RS00645 Protein ID WP_003083773.1
Coordinates 141541..141822 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag QJ974_RS00650 Protein ID WP_003083775.1
Coordinates 141819..142046 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ974_RS00620 (QJ974_00620) 136792..138141 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
QJ974_RS00625 (QJ974_00625) 138190..138876 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QJ974_RS00630 (QJ974_00630) 138977..139711 + 735 WP_003117208.1 GntR family transcriptional regulator -
QJ974_RS00635 (QJ974_00635) 139891..140301 + 411 WP_003101225.1 aegerolysin family protein -
QJ974_RS00640 (QJ974_00640) 140333..141241 - 909 WP_003083769.1 LysR family transcriptional regulator -
QJ974_RS00645 (QJ974_00645) 141541..141822 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
QJ974_RS00650 (QJ974_00650) 141819..142046 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
QJ974_RS00655 (QJ974_00655) 142222..142842 - 621 WP_003101226.1 hypothetical protein -
QJ974_RS00660 (QJ974_00660) 142943..143443 + 501 WP_003112629.1 LEA type 2 family protein -
QJ974_RS00665 (QJ974_00665) 143516..143857 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QJ974_RS00670 (QJ974_00670) 143939..145366 - 1428 WP_003083784.1 GABA permease -
QJ974_RS00675 (QJ974_00675) 145535..147028 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T281058 WP_003083773.1 NZ_CP124670:c141822-141541 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT281058 WP_003083775.1 NZ_CP124670:c142046-141819 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References