281056

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4647872..4649130 Replicon chromosome
Accession NZ_CP124669
Organism Pseudomonas aeruginosa strain 2021CK-01494

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag QKA38_RS21610 Protein ID WP_003086331.1
Coordinates 4647872..4648627 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QKA38_RS21615 Protein ID WP_003086329.1
Coordinates 4648762..4649130 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKA38_RS21600 (QKA38_21600) 4643041..4645584 + 2544 WP_023097910.1 acyl-homoserine-lactone acylase QuiP -
QKA38_RS21605 (QKA38_21605) 4645739..4647100 - 1362 WP_073647918.1 DNA recombination protein RmuC -
QKA38_RS21610 (QKA38_21610) 4647872..4648627 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
QKA38_RS21615 (QKA38_21615) 4648762..4649130 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QKA38_RS21620 (QKA38_21620) 4649203..4650489 - 1287 WP_023097911.1 FAD-binding oxidoreductase -
QKA38_RS21625 (QKA38_21625) 4650545..4652038 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
QKA38_RS21630 (QKA38_21630) 4652213..4652689 + 477 WP_003140638.1 hypothetical protein -
QKA38_RS21635 (QKA38_21635) 4652692..4652967 - 276 WP_023098713.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T281056 WP_003086331.1 NZ_CP124669:c4648627-4647872 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT281056 WP_003086329.1 NZ_CP124669:c4649130-4648762 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References