281055

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3675202..3676422 Replicon chromosome
Accession NZ_CP124669
Organism Pseudomonas aeruginosa strain 2021CK-01494

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag QKA38_RS17065 Protein ID WP_003110488.1
Coordinates 3675844..3676422 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QKA38_RS17060 Protein ID WP_003088112.1
Coordinates 3675202..3675756 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKA38_RS17035 (QKA38_17035) 3670770..3671321 + 552 WP_003132721.1 XRE family transcriptional regulator -
QKA38_RS17040 (QKA38_17040) 3671318..3671716 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
QKA38_RS17045 (QKA38_17045) 3671729..3672052 - 324 WP_003102734.1 multidrug efflux SMR transporter -
QKA38_RS17050 (QKA38_17050) 3672383..3672844 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
QKA38_RS17055 (QKA38_17055) 3672849..3675044 + 2196 WP_023097736.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
QKA38_RS17060 (QKA38_17060) 3675202..3675756 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
QKA38_RS17065 (QKA38_17065) 3675844..3676422 + 579 WP_003110488.1 HD domain-containing protein Toxin
QKA38_RS17070 (QKA38_17070) 3676532..3677719 - 1188 WP_003110489.1 HlyD family efflux transporter periplasmic adaptor subunit -
QKA38_RS17075 (QKA38_17075) 3677709..3679880 - 2172 WP_023097737.1 type I secretion system permease/ATPase -
QKA38_RS17080 (QKA38_17080) 3679870..3681147 - 1278 WP_023097738.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T281055 WP_003110488.1 NZ_CP124669:3675844-3676422 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT281055 WP_003088112.1 NZ_CP124669:3675202-3675756 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References