Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1851477..1852985 Replicon chromosome
Accession NZ_CP124669
Organism Pseudomonas aeruginosa strain 2021CK-01494

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag QKA38_RS08640 Protein ID WP_003119682.1
Coordinates 1851477..1852064 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag QKA38_RS08645 Protein ID WP_023097364.1
Coordinates 1852131..1852985 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKA38_RS08635 (QKA38_08635) 1847732..1851211 - 3480 WP_003091610.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
QKA38_RS08640 (QKA38_08640) 1851477..1852064 + 588 WP_003119682.1 GNAT family protein Toxin
QKA38_RS08645 (QKA38_08645) 1852131..1852985 + 855 WP_023097364.1 AraC family transcriptional regulator Antitoxin
QKA38_RS08650 (QKA38_08650) 1853082..1855247 + 2166 WP_023097365.1 TonB-dependent receptor family protein -
QKA38_RS08655 (QKA38_08655) 1855422..1857296 + 1875 WP_003117607.1 MFS transporter -
QKA38_RS08660 (QKA38_08660) 1857357..1857566 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T281054 WP_003119682.1 NZ_CP124669:1851477-1852064 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31967.26 Da        Isoelectric Point: 7.3276

>AT281054 WP_023097364.1 NZ_CP124669:1852131-1852985 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAEQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure

References