281053

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1580147..1581842 Replicon chromosome
Accession NZ_CP124669
Organism Pseudomonas aeruginosa strain 2021CK-01494

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag QKA38_RS07385 Protein ID WP_023097317.1
Coordinates 1580147..1581016 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1C7C9F9
Locus tag QKA38_RS07390 Protein ID WP_017001846.1
Coordinates 1581009..1581842 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKA38_RS07360 (QKA38_07360) 1576155..1577006 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
QKA38_RS07365 (QKA38_07365) 1577047..1578054 + 1008 WP_023097315.1 ABC transporter substrate-binding protein -
QKA38_RS07370 (QKA38_07370) 1578051..1578827 + 777 WP_003112898.1 ABC transporter permease -
QKA38_RS07375 (QKA38_07375) 1578833..1579594 + 762 WP_023097316.1 SDR family oxidoreductase -
QKA38_RS07380 (QKA38_07380) 1579608..1580138 + 531 WP_003112900.1 cupin domain-containing protein -
QKA38_RS07385 (QKA38_07385) 1580147..1581016 + 870 WP_023097317.1 alpha/beta hydrolase Toxin
QKA38_RS07390 (QKA38_07390) 1581009..1581842 + 834 WP_017001846.1 IclR family transcriptional regulator Antitoxin
QKA38_RS07395 (QKA38_07395) 1581829..1582626 + 798 WP_017001845.1 SDR family oxidoreductase -
QKA38_RS07400 (QKA38_07400) 1582619..1584301 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
QKA38_RS07405 (QKA38_07405) 1584312..1585115 + 804 WP_003112905.1 aspartate dehydrogenase -
QKA38_RS07410 (QKA38_07410) 1585127..1586611 + 1485 WP_023097318.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30405.65 Da        Isoelectric Point: 6.5921

>T281053 WP_023097317.1 NZ_CP124669:1580147-1581016 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSSP
LPPAWPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30867.22 Da        Isoelectric Point: 5.7725

>AT281053 WP_017001846.1 NZ_CP124669:1581009-1581842 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRSHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7C9F9

References