281052

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 152432..152937 Replicon chromosome
Accession NZ_CP124669
Organism Pseudomonas aeruginosa strain 2021CK-01494

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag QKA38_RS00695 Protein ID WP_003083773.1
Coordinates 152432..152713 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag QKA38_RS00700 Protein ID WP_003083775.1
Coordinates 152710..152937 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKA38_RS00670 (QKA38_00670) 147683..149032 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
QKA38_RS00675 (QKA38_00675) 149081..149767 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QKA38_RS00680 (QKA38_00680) 149868..150602 + 735 WP_003110658.1 GntR family transcriptional regulator -
QKA38_RS00685 (QKA38_00685) 150782..151192 + 411 WP_003110659.1 aegerolysin family protein -
QKA38_RS00690 (QKA38_00690) 151224..152132 - 909 WP_003083769.1 LysR family transcriptional regulator -
QKA38_RS00695 (QKA38_00695) 152432..152713 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
QKA38_RS00700 (QKA38_00700) 152710..152937 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
QKA38_RS00705 (QKA38_00705) 153113..153733 - 621 WP_003101226.1 hypothetical protein -
QKA38_RS00710 (QKA38_00710) 153834..154334 + 501 WP_003101228.1 LEA type 2 family protein -
QKA38_RS00715 (QKA38_00715) 154407..154748 + 342 WP_023098307.1 zinc ribbon domain-containing protein YjdM -
QKA38_RS00720 (QKA38_00720) 154830..156257 - 1428 WP_003083784.1 GABA permease -
QKA38_RS00725 (QKA38_00725) 156426..157919 - 1494 WP_023098308.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T281052 WP_003083773.1 NZ_CP124669:c152713-152432 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT281052 WP_003083775.1 NZ_CP124669:c152937-152710 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References