Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3675157..3676377 Replicon chromosome
Accession NZ_CP124668
Organism Pseudomonas aeruginosa strain 2021CK-01445

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag QJ951_RS17065 Protein ID WP_003110488.1
Coordinates 3675799..3676377 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag QJ951_RS17060 Protein ID WP_003088112.1
Coordinates 3675157..3675711 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ951_RS17035 (QJ951_17035) 3670725..3671276 + 552 WP_003132721.1 XRE family transcriptional regulator -
QJ951_RS17040 (QJ951_17040) 3671273..3671671 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
QJ951_RS17045 (QJ951_17045) 3671684..3672007 - 324 WP_003102734.1 multidrug efflux SMR transporter -
QJ951_RS17050 (QJ951_17050) 3672338..3672799 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
QJ951_RS17055 (QJ951_17055) 3672804..3674999 + 2196 WP_023097736.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
QJ951_RS17060 (QJ951_17060) 3675157..3675711 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
QJ951_RS17065 (QJ951_17065) 3675799..3676377 + 579 WP_003110488.1 HD domain-containing protein Toxin
QJ951_RS17070 (QJ951_17070) 3676487..3677674 - 1188 WP_003110489.1 HlyD family efflux transporter periplasmic adaptor subunit -
QJ951_RS17075 (QJ951_17075) 3677664..3679835 - 2172 WP_023097737.1 type I secretion system permease/ATPase -
QJ951_RS17080 (QJ951_17080) 3679825..3681102 - 1278 WP_023097738.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T281049 WP_003110488.1 NZ_CP124668:3675799-3676377 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT281049 WP_003088112.1 NZ_CP124668:3675157-3675711 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References