281043

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4982098..4982706 Replicon chromosome
Accession NZ_CP124667
Organism Pseudomonas aeruginosa strain 2021CK-01315

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag QKA52_RS23280 Protein ID WP_003114156.1
Coordinates 4982098..4982445 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A643EG04
Locus tag QKA52_RS23285 Protein ID WP_042857565.1
Coordinates 4982455..4982706 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKA52_RS23250 (QKA52_23250) 4977518..4977730 + 213 WP_275988278.1 cysteine-rich CWC family protein -
QKA52_RS23255 (QKA52_23255) 4977730..4978422 + 693 WP_023104853.1 16S rRNA pseudouridine(516) synthase -
QKA52_RS23260 (QKA52_23260) 4978558..4979601 + 1044 WP_003098363.1 L,D-transpeptidase -
QKA52_RS23265 (QKA52_23265) 4979681..4980418 + 738 WP_172773749.1 murein L,D-transpeptidase catalytic domain family protein -
QKA52_RS23270 (QKA52_23270) 4980870..4981772 + 903 WP_003123042.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
QKA52_RS23280 (QKA52_23280) 4982098..4982445 - 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QKA52_RS23285 (QKA52_23285) 4982455..4982706 - 252 WP_042857565.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QKA52_RS23290 (QKA52_23290) 4982920..4983903 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
QKA52_RS23295 (QKA52_23295) 4983903..4985195 - 1293 WP_003454977.1 hypothetical protein -
QKA52_RS23300 (QKA52_23300) 4985454..4986716 - 1263 WP_282414015.1 zonular occludens toxin domain-containing protein -
QKA52_RS23305 (QKA52_23305) 4986718..4987068 - 351 WP_003159569.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4982098..5002623 20525


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T281043 WP_003114156.1 NZ_CP124667:c4982445-4982098 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9456.81 Da        Isoelectric Point: 9.4808

>AT281043 WP_042857565.1 NZ_CP124667:c4982706-4982455 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGIPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A643EG04

References