Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 1949820..1951078 Replicon chromosome
Accession NZ_CP124667
Organism Pseudomonas aeruginosa strain 2021CK-01315

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QKA52_RS09135 Protein ID WP_003163133.1
Coordinates 1950323..1951078 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QKA52_RS09130 Protein ID WP_003086329.1
Coordinates 1949820..1950188 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKA52_RS09110 (QKA52_09110) 1945983..1946258 + 276 WP_010792073.1 zinc ribbon domain-containing protein -
QKA52_RS09115 (QKA52_09115) 1946261..1946737 - 477 WP_003112531.1 hypothetical protein -
QKA52_RS09120 (QKA52_09120) 1946912..1948405 + 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
QKA52_RS09125 (QKA52_09125) 1948461..1949747 + 1287 WP_003163134.1 FAD-binding oxidoreductase -
QKA52_RS09130 (QKA52_09130) 1949820..1950188 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QKA52_RS09135 (QKA52_09135) 1950323..1951078 + 756 WP_003163133.1 RES family NAD+ phosphorylase Toxin
QKA52_RS09140 (QKA52_09140) 1951846..1953207 + 1362 WP_003081943.1 DNA recombination protein RmuC -
QKA52_RS09145 (QKA52_09145) 1953362..1955905 - 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28250.37 Da        Isoelectric Point: 7.7294

>T281040 WP_003163133.1 NZ_CP124667:1950323-1951078 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT281040 WP_003086329.1 NZ_CP124667:1949820-1950188 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References