Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1632297..1633992 Replicon chromosome
Accession NZ_CP124667
Organism Pseudomonas aeruginosa strain 2021CK-01315

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag QKA52_RS07580 Protein ID WP_003112901.1
Coordinates 1632297..1633166 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag QKA52_RS07585 Protein ID WP_003112902.1
Coordinates 1633159..1633992 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKA52_RS07555 (QKA52_07555) 1628305..1629156 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
QKA52_RS07560 (QKA52_07560) 1629197..1630204 + 1008 WP_023088129.1 ABC transporter substrate-binding protein -
QKA52_RS07565 (QKA52_07565) 1630201..1630977 + 777 WP_003112898.1 ABC transporter permease -
QKA52_RS07570 (QKA52_07570) 1630983..1631744 + 762 WP_003112899.1 SDR family oxidoreductase -
QKA52_RS07575 (QKA52_07575) 1631758..1632288 + 531 WP_003112900.1 cupin domain-containing protein -
QKA52_RS07580 (QKA52_07580) 1632297..1633166 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
QKA52_RS07585 (QKA52_07585) 1633159..1633992 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
QKA52_RS07590 (QKA52_07590) 1633979..1634776 + 798 WP_017001845.1 SDR family oxidoreductase -
QKA52_RS07595 (QKA52_07595) 1634769..1636451 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
QKA52_RS07600 (QKA52_07600) 1636462..1637265 + 804 WP_003130116.1 aspartate dehydrogenase -
QKA52_RS07605 (QKA52_07605) 1637277..1638761 + 1485 WP_003453562.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T281039 WP_003112901.1 NZ_CP124667:1632297-1633166 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT281039 WP_003112902.1 NZ_CP124667:1633159-1633992 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References