Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 147454..147959 Replicon chromosome
Accession NZ_CP124667
Organism Pseudomonas aeruginosa strain 2021CK-01315

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag QKA52_RS00660 Protein ID WP_023518248.1
Coordinates 147454..147735 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag QKA52_RS00665 Protein ID WP_003083775.1
Coordinates 147732..147959 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QKA52_RS00635 (QKA52_00635) 142705..144054 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
QKA52_RS00640 (QKA52_00640) 144103..144789 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
QKA52_RS00645 (QKA52_00645) 144890..145624 + 735 WP_003110658.1 GntR family transcriptional regulator -
QKA52_RS00650 (QKA52_00650) 145804..146214 + 411 WP_003101225.1 aegerolysin family protein -
QKA52_RS00655 (QKA52_00655) 146246..147154 - 909 WP_003083769.1 LysR family transcriptional regulator -
QKA52_RS00660 (QKA52_00660) 147454..147735 - 282 WP_023518248.1 type II toxin-antitoxin system toxin ParE Toxin
QKA52_RS00665 (QKA52_00665) 147732..147959 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
QKA52_RS00670 (QKA52_00670) 148135..148755 - 621 WP_003101226.1 hypothetical protein -
QKA52_RS00675 (QKA52_00675) 148856..149356 + 501 WP_003101228.1 LEA type 2 family protein -
QKA52_RS00680 (QKA52_00680) 149429..149770 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
QKA52_RS00685 (QKA52_00685) 149852..151279 - 1428 WP_003083784.1 GABA permease -
QKA52_RS00690 (QKA52_00690) 151448..152941 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10472.23 Da        Isoelectric Point: 10.0435

>T281038 WP_023518248.1 NZ_CP124667:c147735-147454 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLPLERWPFSAPFRVKGKE
IQILRIDRIEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT281038 WP_003083775.1 NZ_CP124667:c147959-147732 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References