Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4558803..4560061 Replicon chromosome
Accession NZ_CP124666
Organism Pseudomonas aeruginosa strain 2021CK-01283

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag QJ983_RS21210 Protein ID WP_003086331.1
Coordinates 4558803..4559558 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QJ983_RS21215 Protein ID WP_003086329.1
Coordinates 4559693..4560061 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ983_RS21200 (QJ983_21200) 4553974..4556517 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
QJ983_RS21205 (QJ983_21205) 4556672..4558033 - 1362 WP_073647918.1 DNA recombination protein RmuC -
QJ983_RS21210 (QJ983_21210) 4558803..4559558 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
QJ983_RS21215 (QJ983_21215) 4559693..4560061 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QJ983_RS21220 (QJ983_21220) 4560131..4561417 - 1287 WP_033994983.1 FAD-binding oxidoreductase -
QJ983_RS21225 (QJ983_21225) 4561473..4562966 - 1494 WP_033994982.1 aldehyde dehydrogenase family protein -
QJ983_RS21230 (QJ983_21230) 4563140..4563616 + 477 WP_033994996.1 elongation factor GreAB -
QJ983_RS21235 (QJ983_21235) 4563619..4563894 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T281036 WP_003086331.1 NZ_CP124666:c4559558-4558803 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT281036 WP_003086329.1 NZ_CP124666:c4560061-4559693 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References