Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4543790..4545048 Replicon chromosome
Accession NZ_CP124665
Organism Pseudomonas aeruginosa strain 2021CK-01229

Toxin (Protein)


Gene name - Uniprot ID V6AJ34
Locus tag QJ956_RS21090 Protein ID WP_003086331.1
Coordinates 4543790..4544545 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QJ956_RS21095 Protein ID WP_003086329.1
Coordinates 4544680..4545048 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ956_RS21080 (QJ956_21080) 4538961..4541504 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
QJ956_RS21085 (QJ956_21085) 4541659..4543020 - 1362 WP_073647918.1 DNA recombination protein RmuC -
QJ956_RS21090 (QJ956_21090) 4543790..4544545 - 756 WP_003086331.1 RES family NAD+ phosphorylase Toxin
QJ956_RS21095 (QJ956_21095) 4544680..4545048 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QJ956_RS21100 (QJ956_21100) 4545118..4546404 - 1287 WP_033994983.1 FAD-binding oxidoreductase -
QJ956_RS21105 (QJ956_21105) 4546460..4547953 - 1494 WP_033994982.1 aldehyde dehydrogenase family protein -
QJ956_RS21110 (QJ956_21110) 4548127..4548603 + 477 WP_033994996.1 elongation factor GreAB -
QJ956_RS21115 (QJ956_21115) 4548606..4548881 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28236.34 Da        Isoelectric Point: 7.7294

>T281030 WP_003086331.1 NZ_CP124665:c4544545-4543790 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT281030 WP_003086329.1 NZ_CP124665:c4545048-4544680 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AJ34

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References