Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2930080..2930794 Replicon chromosome
Accession NC_018143
Organism Mycobacterium tuberculosis H37Rv

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag RVBD_RS13770 Protein ID WP_003413460.1
Coordinates 2930354..2930794 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag RVBD_RS13765 Protein ID WP_003413456.1
Coordinates 2930080..2930367 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
RVBD_RS13730 2925502..2925747 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
RVBD_RS13735 2925744..2926148 + 405 WP_003899389.1 type II toxin-antitoxin system VapC family toxin -
RVBD_RS13740 2926365..2926985 + 621 WP_003413441.1 DUF4178 domain-containing protein -
RVBD_RS13745 2926996..2927490 + 495 WP_003413444.1 DUF2617 family protein -
RVBD_RS13750 2927487..2927918 + 432 WP_003899390.1 DUF4247 domain-containing protein -
RVBD_RS13755 2927973..2928401 + 429 WP_178121172.1 DUF350 domain-containing protein -
RVBD_RS13760 2928398..2929969 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
RVBD_RS13765 2930080..2930367 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
RVBD_RS13770 2930354..2930794 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
RVBD_RS13775 2930815..2931570 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
RVBD_RS13780 2931703..2932299 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
RVBD_RS13785 2932307..2933152 - 846 WP_003413466.1 acyl-CoA thioesterase II -
RVBD_RS13790 2933181..2934080 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
RVBD_RS13795 2934208..2934882 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T28103 WP_003413460.1 NC_018143:2930354-2930794 [Mycobacterium tuberculosis H37Rv]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T28103 NC_018143:2930354-2930794 [Mycobacterium tuberculosis H37Rv]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT28103 WP_003413456.1 NC_018143:2930080-2930367 [Mycobacterium tuberculosis H37Rv]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT28103 NC_018143:2930080-2930367 [Mycobacterium tuberculosis H37Rv]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References