281024

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 4855129..4855737 Replicon chromosome
Accession NZ_CP124664
Organism Pseudomonas aeruginosa strain 2021CK-01256

Toxin (Protein)


Gene name PfiT Uniprot ID -
Locus tag QJ960_RS22635 Protein ID WP_033979326.1
Coordinates 4855129..4855476 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag QJ960_RS22640 Protein ID WP_003114155.1
Coordinates 4855486..4855737 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ960_RS22605 (QJ960_22605) 4850548..4850760 + 213 WP_034047704.1 cysteine-rich CWC family protein -
QJ960_RS22610 (QJ960_22610) 4850760..4851452 + 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
QJ960_RS22615 (QJ960_22615) 4851588..4852631 + 1044 WP_003110811.1 L,D-transpeptidase -
QJ960_RS22620 (QJ960_22620) 4852711..4853448 + 738 WP_003085453.1 murein L,D-transpeptidase catalytic domain family protein -
QJ960_RS22625 (QJ960_22625) 4853900..4854802 + 903 WP_034047702.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
QJ960_RS22635 (QJ960_22635) 4855129..4855476 - 348 WP_033979326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QJ960_RS22640 (QJ960_22640) 4855486..4855737 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
QJ960_RS22645 (QJ960_22645) 4855951..4856934 - 984 WP_100212559.1 tyrosine-type recombinase/integrase -
QJ960_RS22650 (QJ960_22650) 4856934..4858226 - 1293 WP_100212560.1 hypothetical protein -
QJ960_RS22655 (QJ960_22655) 4858485..4859747 - 1263 WP_121410774.1 zonular occludens toxin domain-containing protein -
QJ960_RS22660 (QJ960_22660) 4859749..4860099 - 351 WP_003159569.1 DUF2523 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage catB7 - 4855129..4877943 22814


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13018.79 Da        Isoelectric Point: 4.4212

>T281024 WP_033979326.1 NZ_CP124664:c4855476-4855129 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT281024 WP_003114155.1 NZ_CP124664:c4855737-4855486 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References