Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4516086..4517344 Replicon chromosome
Accession NZ_CP124664
Organism Pseudomonas aeruginosa strain 2021CK-01256

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag QJ960_RS20960 Protein ID WP_034047924.1
Coordinates 4516086..4516841 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag QJ960_RS20965 Protein ID WP_003086329.1
Coordinates 4516976..4517344 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QJ960_RS20950 (QJ960_20950) 4511258..4513801 + 2544 WP_034047923.1 acyl-homoserine-lactone acylase QuiP -
QJ960_RS20955 (QJ960_20955) 4513956..4515317 - 1362 WP_003081943.1 DNA recombination protein RmuC -
QJ960_RS20960 (QJ960_20960) 4516086..4516841 - 756 WP_034047924.1 RES family NAD+ phosphorylase Toxin
QJ960_RS20965 (QJ960_20965) 4516976..4517344 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
QJ960_RS20970 (QJ960_20970) 4517417..4518703 - 1287 WP_003163134.1 FAD-binding oxidoreductase -
QJ960_RS20975 (QJ960_20975) 4518759..4520252 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
QJ960_RS20980 (QJ960_20980) 4520427..4520903 + 477 WP_003140638.1 hypothetical protein -
QJ960_RS20985 (QJ960_20985) 4520906..4521181 - 276 WP_170870716.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28304.46 Da        Isoelectric Point: 7.7080

>T281022 WP_034047924.1 NZ_CP124664:c4516841-4516086 [Pseudomonas aeruginosa]
VSEIWRQCKGERYIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT281022 WP_003086329.1 NZ_CP124664:c4517344-4516976 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References