Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 3592688..3593909 | Replicon | chromosome |
| Accession | NZ_CP124664 | ||
| Organism | Pseudomonas aeruginosa strain 2021CK-01256 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | QJ960_RS16610 | Protein ID | WP_003117667.1 |
| Coordinates | 3593331..3593909 (+) | Length | 193 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | QJ960_RS16605 | Protein ID | WP_003088112.1 |
| Coordinates | 3592688..3593242 (+) | Length | 185 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QJ960_RS16580 (QJ960_16580) | 3588256..3588807 | + | 552 | WP_003132721.1 | XRE family transcriptional regulator | - |
| QJ960_RS16585 (QJ960_16585) | 3588804..3589202 | - | 399 | WP_003088123.1 | NADH-quinone oxidoreductase subunit A | - |
| QJ960_RS16590 (QJ960_16590) | 3589215..3589538 | - | 324 | WP_003102734.1 | multidrug efflux SMR transporter | - |
| QJ960_RS16595 (QJ960_16595) | 3589869..3590330 | + | 462 | WP_003102736.1 | (2Fe-2S)-binding protein | - |
| QJ960_RS16600 (QJ960_16600) | 3590335..3592530 | + | 2196 | WP_016263578.1 | xanthine dehydrogenase family protein molybdopterin-binding subunit | - |
| QJ960_RS16605 (QJ960_16605) | 3592688..3593242 | + | 555 | WP_003088112.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| QJ960_RS16610 (QJ960_16610) | 3593331..3593909 | + | 579 | WP_003117667.1 | HD domain-containing protein | Toxin |
| QJ960_RS16615 (QJ960_16615) | 3594018..3595205 | - | 1188 | WP_003102741.1 | HlyD family efflux transporter periplasmic adaptor subunit | - |
| QJ960_RS16620 (QJ960_16620) | 3595195..3597366 | - | 2172 | WP_003114950.1 | type I secretion system permease/ATPase | - |
| QJ960_RS16625 (QJ960_16625) | 3597356..3598633 | - | 1278 | WP_003102743.1 | TolC family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 193 a.a. Molecular weight: 21899.72 Da Isoelectric Point: 5.3655
>T281021 WP_003117667.1 NZ_CP124664:3593331-3593909 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDT
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDT
Download Length: 579 bp
Antitoxin
Download Length: 185 a.a. Molecular weight: 20454.63 Da Isoelectric Point: 8.1590
>AT281021 WP_003088112.1 NZ_CP124664:3592688-3593242 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL
Download Length: 555 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|